South
PA 222 (Hamilton Boulevard) heads south out of Allentown to a six-ramp parclo interchange with I-78/PA 309 opposite of the north end of U.S. 222.
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Interstate 78 overlaps with PA 309 along an older freeway to the southwest of Allentown. I-78 travels east toward Bethlehem and Easton and west toward Harrisburg.
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U.S. 222 shifts onto a freeway bypass of Reading west from U.S. 222 Business (Allentown Pike).
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U.S. 222 (Park Road Extension) converges with U.S. 422 and PA 12 along the Warren Street Bypass in the borough of Wyomissing.
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U.S. 422 shifts southeast from the Warren Street Bypass with U.S. 222 alongside the Schuylkill River around the city of Reading.
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The Warren Street Bypass extends northeast from U.S. 222/422 into Reading as Pennsylvania Route 12.
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U.S. 422 follows the West Shore Bypass southeast toward Pottstown and Philadelphia. U.S. 222 south and U.S. 422 west combine through Wyomissing.
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South 
West
U.S. 222/422 overtake the Warren Street Bypass from PA 12 a quarter mile from the exchange with Paper Mill Road.
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U.S. 222 was aligned onto the Warren Street Bypass (U.S. 422) upon completion of the freeway near Shillington.
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The folded diamond interchange with Paper Mill Road also connects U.S. 222/422 with Crossing Drive and Woodland Road to Berkshire Mall.
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U.S. 222/422 (Warren Street Bypass) curve southward by Berkshire Mall to a parclo B2 interchange with State Hill Road (SR 3023).
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U.S. 422 west splits with U.S. 222 south at Penn Avenue one half mile beyond State Hill Road.
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State Hill Road angles northwest from Wyomissing to State Hill and heads south from U.S. 222/422 to Wyomissing Boulevard.
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U.S. 422 branches west from U.S. 222 (Warren Street Bypass) at a wye interchange to Penn Avenue. U.S. 422 overtakes Penn Avenue from U.S. 422 Business nearby toward Sinking Spring.
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U.S. 422 travels 24 miles west from U.S. 222 in Wyomissing to Lebanon.
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South
A folded diamond interchange connects U.S. 222 with U.S. 422 Business (Penn Avenue) east to Wyomissing, West Reading and Reading.
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Representing the pre-freeway alignment of U.S. 422, U.S. 422 Business (Penn Avenue) heads two miles east to West Reading and 2.8 miles into Downtown Reading.
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The succeeding segment of freeway along U.S. 222 south from U.S. 422 Business (Penn Avenue) to PA 724 (Revere Boulevard) opened in 2001.
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PA 724 (Revere Boulevard) leads southeast to U.S. 222 Business and the borough of Shillington. West from U.S. 222, PA 724 follows Shillington Road north to U.S. 422 (Penn Avenue) in Sinking Spring.
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PA 724 combines with U.S. 222 Business east into Shillington.
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Crossing over the Pennsylvania Turnpike (I-76).
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West South
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South
U.S. 222/PA 272 (Prince Street) south at Mifflin Street, one block from PA 462 (King Street) east in Lancaster.
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The one way couplet for U.S. 222 along Prince Street south and Highland Avenue north concludes at Willow Street Pike in West Lampeter township.
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Willow Street Pike separates into a one way couplet ahead of PA 741 (Long Lane).
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U.S. 222 (Robert Fulton Highway) and PA 272 overlap for a half mile between Lancaster Pike and Nottingham Road in southern Lancaster County. The two part ways near Penn Hill. An erroneous U.S. 272 and PA 222 shield assembly was posted at the split until 1997.
May 1995
Connect with:
Interstate 76
U.S. 30
U.S. 322
U.S. 422
Route 272
Page Updated 02-03-2021.