U.S. 178 travels 233.23 miles southeast across the Palmetto State from the North Carolina state line in the Blue Ridge Mountains to U.S. 78 near Dorchester in the LowCountry. Through the Upstate, U.S. 178 joins the Pickens County seat of Pickens with Liberty and the Anderson County seat of Anderson. U.S. 76/178 overlap 23.54 miles east from Anderson to Honea Path.
Continuing southeast, U.S. 178 heads to Donalds in Abbeville County and Hodges in Greenwood County. U.S. 176 combines with U.S. 25 south 15.77 miles through the city of Greenwood before turning east to Saluda. Passing through western Lexington County, U.S. 178 connects Batesburg-Leesville with I-20 and Pelion.
U.S. 178 meets U.S. 321 at North in Orangeburg County and then proceeds southeast parallel to the Edisto River North Fork to Orangeburg. U.S. 178 partitions with U.S. 178 Business, a 4.40 mile long route through Downtown Orangeburg while bypassing the city along overlaps with U.S. 21 and U.S. 601 Truck. U.S. 178 follows the I-26 corridor southeast from the remaining miles to Bowman, Harleyville and U.S. 78 in Dorchester County.
U.S. 178 South Carolina Guides
East
U.S. 178 (Moorefield Memorial Highway) navigates along a winding course 10.46 miles from the North Carolina state line to S.C. 11.
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S.C. 11 traverses mountainous areas of the South Carolina Upstate west to Keowee Toxaway State park and Salem and east to Table Rock State Park.
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S.C. 11 is part of the Cherokee Foothills Scenic Highway.
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U.S. 178 intersects the west end of S.C. 288 (Table Rock Road) 0.23 miles southeast of S.C. 11.
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A 15.26 mile long highway east to U.S. 276 at Travelers Rest, S.C. 288 meets S.C. 8 at Pumpkintown in 6.24 miles.
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U.S. 178 (Moorefield Memorial Highway) expands to a four lane boulevard southward into the city of Pickens.
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U.S. 178 (Ann Street) south at Sparks Lane (Road 296) in Pickens.
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U.S. 178 dog legs east alongside S.C. 183 (Main Street) between Ann and Pendleton Streets in Downtown Pickens.
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S.C. 183 extends 0.21 miles east along Main Street from U.S. 178 to S.C. 8 (Hampton Avenue).
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Entering the city of Liberty, U.S. 178 heads south along Pickens Drive.
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S.C. 93 follows the pre-freeway alignment of U.S. 123 west from Liberty to Norris, Central and Clemson and east to Easley.
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U.S. 178 converges with the south end of S.C. 135 (Anderson Highway) at a wye intersection beyond Five Forks.
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S.C. 135 (Anderson Highway) runs 5.75 miles northeast to S.C. 8 (Pelzer Highway) in the city of Easley.
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U.S. 178 Connector links U.S. 178 with S.C. 28 at U.S. 76 in Anderson, 0.18 miles to the southwest along Pearman Dairy Road.
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U.S. 178 (Liberty Highway) combines with U.S. 76/S.C. 28 Business (Clemson Boulevard) through a heavily commercialized area in north Anderson.
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U.S. 76/178 and S.C. 28 Business overlap south to North Avenue en route to Downtown Anderson.
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| West |
 | U.S. 178 commences westbound from a rural wye intersection with U.S. 78 by Four Hole Swamp near the settlement of Dorchester. 05/26/07 |
 | U.S. 178 (Fairview Road) meets Interstate 20 at a diamond interchange (Exit 39) near Samaria in western Lexington County. 08/05/00 |
 | S.C. 288 (Table Rock Road) stems 15.26 miles east from U.S. 178 (Moorefield Memorial Highway) by Walnut Cove Mountain to U.S. 276 at Marietta. 07/23/04 |
 | U.S. 178 curves west 0.23 miles from S.C. 288 to intersect S.C. 11 (Cherokee Foothills Scenic Highway). 07/23/04 |
 | S.C. 11 travels west to Keowee-Toxaway State Park and the town of Salem and east to Table Rock State Park as part of a 120 mile long route southwest to Walhalla and Lake Hartwell and east to Gaffney. 07/23/04 |
 | U.S. 178 (Moorefield Memorial Highway) parallels the Oolenoy River northwest from S.C. 11 around Little Rock Mountain1. 07/23/04 |
 | The Rock Golf Course & Resort lies just north of S.C. 11 and east of U.S. 178. 07/23/04 |
 | Navigating through a series of S-curves and switch backs, U.S. 178 climbs northward toward Beasley Gap between Rich and Horse Mountains. 07/23/04 |
 | F. Van Clayton Memorial Highway (Road 199) ties into U.S. 178 at the settlement of Rocky Bottom. 07/23/04 |
 | U.S. 178 crosses Eastatoe Creek between Narrow Ridge and Chimneytop. 07/23/04 |
Connect with:
Interstate 20
Interstate 85
Interstate 95
U.S. 1
U.S. 21
U.S. 25
U.S. 76
U.S. 123
U.S. 301
U.S. 321
U.S. 601
Page Updated 09-16-2021.