South
U.S. 21 (Columbia Road) lowers to cross Sandy Run south from the split with U.S. 176 (Old State Road).
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U.S. 21 south enters an eastern notch of Lexington County at the community of Oak Grove.
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U.S. 21 converges with Interstate 26 at a parclo A2 interchange (Exit 129).
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Interstate 26 travels northwest back toward Columbia.
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Passing east of Orangeburg, Interstate 26 continues southward to the LowCountry and Charleston.
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U.S. 21 descends south from the exchange with I-26 to cross Big Beaver Creek.
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Reentering Calhoun County south of Big Beaver Creek.
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S.C. 6 runs east from the town of Swansea in Lexington County to combine with U.S. 21 at Sunny Plain Road (Road 30).
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South 
East
S.C. 6 overlaps with U.S. 21 south for 1.57 miles.
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S.C. 6 branches east to Saint Matthews.
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South
S.C. 172 (Bull Swamp Road) stems 9.00 miles west from S.C. 6 and U.S. 21 to U.S. 178 near North.
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U.S. 21 (Columbia Road) south at Murph Mill Road (Road 16).
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Burke Road (Road 22) links U.S. 21 with Interstate 26, 0.71 miles to the east.
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U.S. 21 combines with U.S. 178 (Chestnut Street) to encircle the city of Orangeburg to the east.
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South
U.S. 21/178 (Chestnut Street) south at St. Matthews Road (Road 94).
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U.S. 21 Business commences southwest toward Downtown Orangeburg from U.S. 21/178 alongside U.S. 601 (Magnolia Street).
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U.S. 21 Business and U.S. 601 overlap south to U.S. 301 (John C. Calhoun Drive).
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Truck - South
The truck route for U.S. 601 coincides with U.S. 21/178 (Chestnut Street) south to S.C. 4 (Stonewall Jackson Boulevard).
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The Dr. Emily England Clyburn Pedestrian Bridge spans U.S. 21/178 (Chestnut Street) at the South Carolina State University campus.
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Truck - South
U.S. 21 Business returns to U.S. 21 along Rowesville Road. U.S. 21 turns south toward Branchville while U.S. 601 Truck combines with S.C. 4 (Stonewall Jackson Boulevard) west to U.S. 301/601 south of Downtown Orangeburg.
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Photo Credits:
- 01/03/14 by AARoads. 09/20/21 by .
Connect with:
Interstate 26
U.S. 176
U.S. 178
U.S. 301
U.S. 601
Highway 33
Highway 6
Page Updated 12-31-2021.