State Road 45 forms a 300 mile long highway between Naples and High Springs along western reaches of the Florida peninsula. The route is vastly unsigned as the companion of U.S. 41 through Fort Myers, North Port, Sarasota, Bradenton, Brooksville and Williston. An exception occurs through Tampa, where SR 45 diverges from U.S. 41 as the counterpart to U.S. 41 Business by Port Tampa Bay and into the central business district.
A 3.17 mile long independent section of SR 45 in Tampa runs along Nebraska Avenue between U.S. 41 Business/SR 60 (Jackson Street / Kennedy Boulevard) and U.S. 41/92 (Hillsborough Avenue). Nebraska Avenue comprises an urban boulevard to the west of Ybor City, paralleling Interstate 275 north from the Downtown Interchange with I-4.
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| Since replaced with a confirming marker for SR 45, an erroneous trailblazer for U.S. 41 north preceding the intersection with U.S. 41 Business north and SR 60 west (Kennedy Boulevard) along Nebraska Avenue. 09/25/15, 04/23/21 |
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| U.S. 41 Business/SR 60 (Kennedy Boulevard) continue southwest from SR 45 (Nebraska Avenue) into Downtown Tampa. 04/23/21 |
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| An entrance ramp for SR 618 (Lee Roy Selmon Expressway) east immediately follows Kennedy Boulevard from SR 45 north. The Selmon Expressway is a toll road linking Downtown Tampa with Interstate 75 at Brandon. 04/23/21 |
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| The SR 618 eastbound entrance ramp from SR 45 with both older trailblazers for the Tampa Crosstown Expressway posted. 10/28/06 |
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| SR 45 (Nebraska Avenue) passes under the Lee Roy Selmon Expressway (SR 618) ahead of Twiggs Street. The Downtown street connects SR 45 with Curtis Hixon Waterfront Park to the west and provides direct access to the Selmon Express Lanes (SR 618A) east to Brandon Parkway. 04/23/21 |
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| Nebraska Avenue curves north ahead of Nuccio Parkway to Ybor City and Hillsborough Community College. 09/25/15 |
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| Nuccio Parkway branches northeast from SR 45 to the west side of the Ybor City Historic District. Cass Street leads west several blocks into the north Central Business District. 09/25/15 |
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| Scott Street leads east from alongside I-275 to intersect SR 45 (Nebraska Avenue) ahead of a northern turn as 10th Street by Nuccio Park. 09/25/15 |
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| Henderson Avenue is a local street linking SR 45 with E 7th Avenue (unsigned CR 574) east into the Ybor City Historic District. 08/12/14 |
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| E 7th Avenue runs through the heart of the Ybor City business district east of Nuccio Parkway to 22nd Street. 08/12/14 |
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| Running across the north side of Ybor City to the Ybor Campus of Hillsborough Community College, Palm Avenue meets Nebraska Avenue at the succeeding northbound traffic light. 08/12/14 |
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| SR 45 (Nebraska Avenue) passes under the Downtown Interchange joining the west end of Interstate 4 with I-275. 08/12/14 |
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| Columbus Drive parallels the north side of I-4 through the Ybor City area as a one way couplet with 17th and 18th Avenues. West from Nebraska Avenue, Columbus Drive continues through Tampa Heights and West Tampa to U.S. 92 (Dale Mabry Highway) at SR 616. 11/07/15 |
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| SR 45 (Nebraska Avenue) intersects Floribraska and 21st Avenues a quarter mile beyond Columbus Drive. A half diamond interchange lies two blocks to the west with Interstate 275 north. 01/17/20 |
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| Floribraska Avenue links SR 45 (Nebraska Avenue) with the couplet of U.S. 41 Business (Tampa Street / Florida Avenue) at the Tampa Heights neighborhood. E 21st Avenue extends the street toward College Hill. 01/17/20 |
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| A reassurance marker for SR 45 appears beyond Floribraska Avenue. 08/12/14 |
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| Lake Avenue passes under I-275 east from U.S. 41 Business (Florida Avenue) north to SR 45 (Nebraska Avenue) en route to Belmont Estates and College Hill. 08/12/14 |
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| SR 45 expands to four lanes through the intersection with SR 574 (Dr. Martin Luther King, Jr. Boulevard). The junction lies just east of a diamond interchange (Exit 46B) with Interstate 275. 09/25/15 |
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| A 23.04 mile long route, SR 574 travels between Drew Park in Tampa and Plant City. Within Tampa, Dr. Martin Luther King, Jr. Boulevard joins the neighborhoods of West Tampa, College Hill and Grant Park among others. 08/12/14 |
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| Continuing north from SR 574, SR 45 (Nebraska Avenue) enters Southeast Seminole Heights in Tampa. 03/31/21 |
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| A second confirming marker north of SR 574 appears along Nebraska Avenue at Genesee Street. 03/31/21 |
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| Chelsea Street passes under I-275 west from Nebraska Street into the Old Seminole Heights neighborhood. 03/31/21 |
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| Osborne Avenue crosses I-275 west from Nebraska Avenue to Hillsborough High School and Florida Avenue (U.S. 41 Business north). 03/31/21 |
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| SR 45 (Nebraska Avenue) advances north to the west split of U.S. 41/92 at Hillsborough Avenue. U.S. 41 is not acknowledged along SR 45 north here and this assembly at Shadowlawn Avenue was removed in 2015. 08/12/14 |
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| U.S. 92 continues west along Hillsborough Avenue into an adjacent parclo interchange with I-275 at Miami Avenue. U.S. 41 and U.S. 41 Business parallel the freeway northward toward Lutz. 03/31/21 |
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| U.S. 92 lines Hillsborough Avenue west to Dale Mabry Highway (SR 580) at Drew Park and east across I-4 en route to Plant City. U.S. 41 overlaps with U.S. 92 east to N 40th Street near Belmont Heights, while rejoining SR 45 north from Seminole Heights to High Springs. 03/31/21 |
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| A reassurance marker was posted just south of the SR 45 separation from U.S. 41 at Hillsborough Avenue. It was removed by 2014. 08/20/06 |
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| SR 45 (Nebraska Avenue) runs through the Southeast Seminole Heights neighborhood between Hillsborough Avenue and Dr. Martin Luther King, Jr. Boulevard.
The state road was restriped from four to two lanes by 2011. A center turn lane and bike lanes were added in addition to faux brick medians. 01/21/22 |
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| Osborne Avenue passes under adjacent I-275 west of this signal with SR 45 to Hillsborough High School and U.S. 41 Business. 01/21/22 |
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| Four blocks further south, motorists along Nebraska Avenue encounter another traffic light at Chelsea Street. 05/26/16 |
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| Nearing Ybor Heights, SR 45 (Nebraska Avenue) intersects SR 574 (Dr. Martin Luther King, Jr. Boulevard). 05/26/16 |
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| SR 574 leads east through East Tampa to exit the city of Tampa at Grant Park en route to Mango, Seffner, Dover and Plant City. Westward, the state road meets I-275 ahead of Old Seminole and Tampa Heights. 05/26/16 |
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| Nebraska Avenue advances southward through Ybor Heights to E 26th Avenue. 08/17/24 |
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| Lake Avenue intersects SR 45 (Nebraska Avenue) west of College Hill and east of Tampa Heights and an underpass below I-275. 09/05/15 |
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| Previous traffic signal configuration at Nebraska Avenue south and Lake Avenue before roadway modifications. 08/20/06 |
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| Upcoming Floribraska Avenue connects the VM Ybor neighborhood with I-275 north at a half diamond interchange. 09/05/15 |
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| Floribraska Avenue links SR 45 (Nebraska Avenue) with U.S. 41 Business (Florida Avenue / Tampa Street). East 21st Avenue extends the street east to Cuscaden Park and East Tampa. 09/05/15 |
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| An SR 45 shield was posted south of Floribraska Avenue at St. Clair Street until 2007. It was not replaced during the streetscaping project of Nebraska Avenue. 05/08/06 |
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| Columbus Drive travels east from SR 45 parallel to Interstate 4 through East Tampa and west to Tampa Heights and MacFarlane Park. 04/23/21 |
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| SR 45 (Nebraska Avenue) south passes below a series of overpasses associated with the Downtown Interchange. 09/05/15 |
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| A high flyover carries drivers from I-275 south onto I-4 east above SR 45 at East 12th Avenue. 04/23/21 |
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| Palm Avenue constitutes a four lane boulevard west to North Boulevard at Ridgewood Park and east to the couplet of 21st and 22nd Streets in Historic Ybor City. 08/17/24 |
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| East 7th Avenue bisects the Historic Ybor City business district from SR 45 (Nebraska Avenue) to 21st and 22nd Streets. The route doubles as unsigned County Road 574 east toward SR 574 at Mango. 04/23/21 |
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| An overhead once directed motorists onto East 7th Avenue from Nebraska Avenue south. This assembly was a likely leftover from when East 7th Avenue was Florida Secondary 574. 08/20/06 |
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| Henderson Avenue branches southwest from East 7th Avenue to intersect SR 45 at the adjacent southbound signal. 04/23/21 |
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| The final reassurance marker for SR 45 south stands beyond Henderson Avenue at Estelle Street. 04/23/21 |
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| Scott Street arcs southwest from 7th Avenue and Nuccio Park to intersect Nebraska Avenue. 04/23/21 |
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| Nuccio Parkway south and Cass Street east come together at the subsequent southbound traffic light as Nebraska Avenue (SR 45) reaches the Downtown area. 04/23/21 |
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| A Tampa Crosstown Expressway once directed motorists to remain along Nebraska Avenue south at the turn off for Twiggs Street. It was removed by August 2006. 03/19/06 |
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| Twiggs Street provides a direct route to SR 60 east / U.S. 41 Business south along Channelside Drive north from SR 45 south. SR 45 defaults onto the pair westbound at Kennedy Boulevard ahead. 04/23/21 |
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| SR 45 (Nebraska Avenue) passes under the Selmon Expressway before reaching an eastbound on-ramp to Brandon. The nearest westbound on-ramp departs from Brorein Street west of Jefferson Streets to the south. 03/19/06 |
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| SR 45 (Nebraska Avenue) passes under the Selmon Expressway (SR 618) before an eastbound on-ramp to Brandon. The nearest westbound on-ramp departs from Brorein Street west of Jefferson Streets to the south. 04/23/21 |
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| U.S. 41 Business is omitted as SR 45 approaches SR 60 west (Kennedy Boulevard). 04/23/21 |
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| U.S. 41 Business / SR 60 utilize a one way couplet through Downtown with eastbound using Jackson Street, one block further south. 04/23/21 |
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| SR 618 (Lee Roy Selmon Expressway) winds northeast from Downtown and Channelside to Ybor City while en route to Interstate 75 and Brandon. 04/23/21 |
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| The south end of SR 45 defaults onto U.S. 41 Business north / SR 60 (Kennedy Boulevard) west as Nebraska Avenue flows northbound only from Jackson Street. 09/05/15 |
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| Trailblazers for I-275 direct motorists from Ybor City onto SR 45 (Nebraska Avenue) from Palm Avenue west. 11/07/15 |
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| Floribraska Avenue east connects I-275 south with SR 45 (Nebraska Avenue) at 21st Avenue. 07/14/16 |
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